VG H&N course intro Florence 2016.pptx

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Radiotherapy or surgery in laryngeal/
hypopharyngeal cancers?
• T/N stage
• A single procedure?
• Partial >< total laryngectomy or pharyngo-
laryngectomy?
• Patient’s co-morbidity, medical history and age
• Patient’s preference
EHNS-ESTRO H&N course
Florence, June 2016
Meta-analysis on altered fractionation HNSCC
Bourhis, Pignon 2006
Randomized trials 1970-1998 (no postop RT)
15 trials included (6515 patients, individual data)
p <0.0001
100
80
60
40
20
0
100
80
60
40
20
0
Loco-regionalrecurrence
Overall survival
EHNS-ESTRO H&N course
Florence, June 2016