1696-1697 / 2351
Xerostomia
Amifostine recommended by ASCO for RT but not for CRT.
d d h
d 2 f
% 3 % (
002)
- re uce c ronic xerostomia gra e rom 57 to 4
P
= .
.
Pilocarpine approved by FDA.
- N =249
- patients randomized between placebo versus pilocarpine 5 mgr
N=249
P-value
P
i
f li
f
i
P 0 05
reservat on o sa vary unct on
< .
Quality of life
P=NS
Gustatory stimuli (chewing, acid substance, saliva substitute, ..)
Buglione et al, Critical Reviews Oncology/hematology 2016
Hensley et al. JCO 2009
Fisher J Int J Radiat Oncol Biol Phys 2003