1756-1757 / 2351
Issues related with chemotherapy
Grade 3/4
Vermorken
Posner
PF vs TPF
PF
vs TPF
Neutropenia
52.5% 76.9%
56% 83%
Th b i
17 9% 5 2%
11%
4%
rom open a
.
.
Febrile neutropenia
2.8% 5.2%
7% 12%
Infection
6.1% 6.9%
5%
6%
Stomatitis
11.2% 4.6%
27% 21%
Prophylactic antibiotics, ciprofloxacine 500mg bid started day 5 for 10 days
Consider prophylactic G-CSF
Posner et al. NEJM 2007; Vermorken et al. NEJM 2007