2018-2019 / 2351
Prognostic factors in patients with recurrent or metastatic SCCHN treated with cisplatin-
based chemotherapy in two phase III trials (E1393 and E1395)
•
0-2 unfavorable prognostic factors: median OS = one year.
•
3-5 unfavorable prognostic factors: median OS = six months (p < 0.0001)
Prognosis
Prognostic factors for poor survival in the multivariate
analysis (n=399)
p
Weight loss > 5%
0.0004
ECOG 1 vs 0
0.0016
Well and moderate differentiation
0.028
Primary tumor oral cavity or hypopharynx
0.011
Prior radiation therapy
<0.0001
Argiris et al Cancer 2004