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BIOLOGICAL STUDIES
DETECTION OF
EPSTEIN-BARR VIRUS
IN A LYMPH NODE
BIOPSY IS USEFUL TO DETECT NASOPHARYNGEAL
CARCINOMA IN THE AREAS WHERE THE DISEASE IS ENDEMIC,
OTHERWISE, ITS VALUE IS LIKELY LIMITED
STRONGLY ASSOCIATED
WITH THE PRESENCE OF
CYSTIC CERVICAL METASTASIS
HPV
EBV
92%
TYPE 16
(FOLLOWED BY TYPE 18, 33 AND 58)
DETERMINATION OF HPV STATUS CAN BE OBTAINED BY FNAC
Lee et al.,Head Neck 2000
Gillison et al., J Natl Cancer Inst 2008
Desai et al., Exp Mol Pathol 2009
Vent el al., Head Neck, 2013
Pavlidis et al., Oral Oncology 2015
von Buchwald C et al, 2014
Pawlita et al, Clin Exp Metastasis, Sept 2015
HPV RELATED SCC ARE GENERALLY DIAGNOSED WITH
EARLIER
T CATEGORY
AND MORE
ADVANCED N CATEGORY
95% OF SCC HPV+ ARE
NON KERATINIZING
85% OF SCC KERATINIZING ARE HPV -
Lewis et al, Head and Neck Patol, 2015
IDENTIFICATION OF THE PRIMARY TUMOR
mercoledì 29 giugno 16