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Stockholm III Trial

Inclusion Criteria: clinically resectable RC < 15 cm from AV

R

5x5 Gy

1 Week

4 to 8 Weeks

TME

TME

5x5 Gy

25 x 2 Gy

TME

4 to 8 Weeks

Primary endpoint: Time to local recurrence, 840 pts to show equality

(15% @ 5y, power 80%)

Secondary: acute, late tox, QoL, overall survival