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The Royal Marsden
Objectives of trial
– recruit patients and stratify treatment using
mrTRG directed management. The ‘good
responders’ (mrTRG1&2) often have no evidence of
tumour and it may be possible to avoid surgery in
this group (deferral of surgery).
– The ‘poor responders’ (mrTRG3-5) are at high risk
of poor oncological outcomes and additional
therapy before surgery may improve prognosis.