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Pelvic OARs constraints: sparing the bladder
- GU toxicity, a relatively minor problem («low»
dose): threshold around 50-55Gy, whole organ
for RTOG G3 late tox (Quantec 2010, Fiorino
2009)
- No strong evidence of increased late GU tox
compared to only surgery (Gilbert 2015)
- Recent important updates of predictors of GU
tox (more relevant for prostate ca pts, Landoni
2016)
- Interplay between bladder filling and bowel
sparing
- The avoidance approach of the peritoneal space
should include bladder to guarantee adequate
sparing of bowel during treatment (possible
systematic deviations)
Sanguineti 2008