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Pelvic OARs constraints: bone marrow

- Main dosimetry predictors (IMRT): coxal

and sacral V45 mostly associated to lower

nadir of WBC and neutrophils (Yang 2014)

- Worst WBC Nadir with 3DCRT

- V40 of whole pelvic BM and iliac BM

predicted acute and late limphopenia in a

Yang 2014

large prostate ca group (wout CHT) treated

with IMRT (Sini 2016)

Sini 2016

Prostate ca pts,

no CHT