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- Margins as the local distance between ref contour and high-probability

contour (for instance 90% ≈ missing 1/9 fractions)

- Splitting the rectum in 8 sectors (anysotropic motion)

- Assessing for each sector the «best» margin value based on the % of voxels

(95-99%) included in the high-probability contour

- Prospectively evaluating the appropriatness on an independent population

ART: margins for the boosting phase

Raso 2015