666 / 1068
Applying LQ model including repopulation:
- Original scheme:
BED = nd (1 + d/
α
/
β
) -
γ
/
α
(T – Tk)
where: d, daily dose, n n
°
fractions,
γ
/
α
repopulation factor (0.6Gy/day), Tk
delay time (7 days),
α
/
β
=10 (Widder et al, 2005)
- Adaptive scheme:
BED = md (1 + d/
α
/
β
) + (n-m)d
adapt
(1 + d
adapt
/
α
/
β
) -
γ
/
α
(T – Tk)
Adaptive RT: choosing the adaptive scheme
Assessing m and d
adapt
to escalate the boost dose to EQD2=54Gy
-
- Practical limitations:
imaging for adaptive boosting not before half-RT
Leaving time for image matching, re-contouring, re-planning, scheduling….