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- MRI @ half therapy (fraction 9)

- Concomitant boost in the last 6

(3 days left)

- Calculating d

adapt

to escalate to

EQD2=54Gy ≈ 3Gy/fr in the last 6

fractions (out of 18)

- Corresponding EQD2 for OAR (late

Adaptive RT: choosing the adaptive scheme

50

55

60

65

70

EQD2 (Gy)

T

OAR (late)

tox, α/β=3) slightly lower than for T

40

45

2

2,5

3

3,5

4

4,5

daily dose (adaptive boost)

No boost ART

Summary of ART scheme:

Fractions 1-12: 2.3 Gy/fr (27.6 Gy) @ PTV1

Fractions 13-18: 2.3 Gy/fr (13.8 Gy) @ PTV1

concomitantly 3.0 Gy/fr (18Gy) @ PTV

boost

Total dose: 41.4Gy PTV1; 45.6Gy PTVboost

(18 fractions)