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ART optimization based on early response ?
- Analyses of MRI-based T
regression correlated with pCR
- May Mid-RT MRI (average
volume reduction: -56%) predict
the pathological response ?
- A poisson-based radiobiological
model, incorporating the
individual early response, well
predicts pCR and residual cells
(Raso, ESTRO 2016)
- Potentials for selection of pts for
ART and adaptation of boost
dose (work in progress…)
TCP
D
=(1-
∆
V
D
)
V_PRE
AUC: 0.87 (specificity: 71.4%, sensitivity: 96.4%)
(not lower discriminative power compared to
post_RT MRI, AUC:0.82 n.s.); n=42 pts