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RT 45 Gy

Cape

RT 50 Gy

CapeOx

P-value

Number of pts

293

291

ypT0/TRG 4 (%)

13.9

19.2

.09

Grade 3/4 Tox

ACCORD 12/0405-Prodige-Trial

Compliance to CRT

Gérard et al., J Clin Oncol 2010

Local Relapse @5y (%)

8.8

7.8

.78

HR 0.92

Disease-free Survival @ 5y (%)

60.4

64.7

4.3%

.25

HR 0.86

Doyen J et al., ESTRO 2016