691 / 1068
RT 50.4 Gy
5-FU
RT 50.4 Gy
5-FU/+Ox
P-value
Number of pts
623
613
pCR (%)
13
17
.04
Grade 3/4 Tox
=/
▲
Compliance to CRT
=
CAO/ARO/AIO-04
Rödel et al., Lancet Oncol 2012
Local Relapse after R0/1 @3y (%)
4.6
2.9
Disease-free Survival @ 3y (%)
71.2
75.9
△
4.7%
.03
HR 0.79
Rödel et al., Lancet Oncol 2015
(full paper from similar PETACC-6 pending)