Microsoft PowerPoint - L00 Introduction

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STAR-01
Inclusion criteria: cT3-4 or N+, ≤ 75 years
R
RT 50.4 Gy (@1.8Gy) +
5-FU c.i. 225 mg/m 2/d
T
M
E
Adjuvant
treatment
5-FU based
Primary endpoint: OS (30% reduction in mortality rates); 690 pts required.
pCR as protocol-planned comparative analysis
RT 50.4 Gy (@1.8Gy) +
5-FU c.i. 225 mg/m2/d
Oxaliplatin 60 mg/m2 weekly
T
M
E
Adjuvant
treatment
5-FU based