Microsoft PowerPoint - L00 Introduction

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RT 50.4 Gy

5-FU or Cape

RT 50.4 Gy

5-FU/Cape+Ox

P-value

Number of pts

636

640

pCR (%)

17.8

19.5

.42

Grade 3/4 Tox

▲

NSAPB R-04

Compliance to CRT

▼

O‘Connell et al., J Clin Oncol 2014

Local Relapse after R0 @3y (%)

5.1

3.1

.21

HR 0.71

Disease-free Survival @ 5y (%)

64.2

69.2

△

5%

.34

HR 0.91

Allegra et al., J Natl Cancer Inst 2015