690 / 1068
CAO/ARO/AIO-04
(similar design PETACC-6)
Inclusion criteria: cT3-4 or N+
R
RT 50.4 Gy
(@1.8Gy)
+
1000 mg/m² days 1-5 + 29-33
T
M
E
5-FU bolus
4 cycles
(4 months)
Primary endpoint: 3y-DFS (75% to 82%); 1200 pts
pCR as unplanned exploratory analysis
RT 50.4 Gy
(@1.8Gy)
+
5-FU: 250 mg/m² d 1-14 + 22-35
Oxaliplatin: 50 mg/m² d 1, 8 + 22, 29
T
M
E
mFOLFOX6
8 cycles
(4 months)