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Three ways to incorporate oxaliplatin into CMT:

Use a pre and postoperative regimen with less tox

and high compliance (CAO/ARO/AIO-04)

Use oxaliplatin after preop 5-FU/Cape CRT in

adjuvant setting only (NCCN-guidelines, ADORE*)

Find better ways ...

*Hong et al., Lancet Oncol 2014