Three ways to incorporate oxaliplatin into CMT:
•
Use a pre and postoperative regimen with less tox
and high compliance (CAO/ARO/AIO-04)
•
Use oxaliplatin after preop 5-FU/Cape CRT in
adjuvant setting only (NCCN-guidelines, ADORE*)
•
Find better ways ...
*Hong et al., Lancet Oncol 2014