MRI-staged T2-3 N0 or T any N+
R
E
S
T
FOLFOX/
CAPOX
(16-18 weeks)
RT 50.4 Gy +
5-FU/Cape
Signi-
ficant
response
N
O
M
MSKCC-Trial
(randomized phase II)
A
G
I
N
G
FOLFOX/
CAPOX
(16-18 weeks)
No
signi-
ficant
response
T
M
E
R
RT 50.4 Gy +
5-FU/Cape