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Version 2.2015, 03/11/15 © National Comprehensive Cancer Network, Inc. 2015, All rights reserved.

The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®.

MS-79

NCCN Guidelines Index

Breast Cancer Table of Contents

Discussion

NCCN Guidelines Version 2.2015

Breast Cancer

with HER2-positive early breast cancer: a randomized phase II cardiac

safety study (TRYPHAENA). Ann Oncol 2013;24:2278-2284. Available

at:

http://www.ncbi.nlm.nih.gov/pubmed/23704196 .

169. Gianni L, Pienkowski T, Im YH, et al. Efficacy and safety of

neoadjuvant pertuzumab and trastuzumab in women with locally

advanced, inflammatory, or early HER2-positive breast cancer

(NeoSphere): a randomised multicentre, open-label, phase 2 trial.

Lancet Oncol 2012;13:25-32. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/22153890

.

170. Ellis MJ, Coop A, Singh B, et al. Letrozole is more effective

neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-

2-positive, estrogen receptor-positive primary breast cancer: evidence

from a phase III randomized trial. J Clin Oncol 2001;19:3808-3816.

Available at:

http://www.ncbi.nlm.nih.gov/pubmed/11559718

.

171. Smith IE, Dowsett M, Ebbs SR, et al. Neoadjuvant treatment of

postmenopausal breast cancer with anastrozole, tamoxifen, or both in

combination: the Immediate Preoperative Anastrozole, Tamoxifen, or

Combined with Tamoxifen (IMPACT) multicenter double-blind

randomized trial. J Clin Oncol 2005;23:5108-5116. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/15998903

.

172. Hellman S. Stopping metastases at their source. N Engl J Med

1997;337:996-997. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/9309106 .

173. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative

radiotherapy in high-risk premenopausal women with breast cancer who

receive adjuvant chemotherapy. Danish Breast Cancer Cooperative

Group 82b Trial. N Engl J Med 1997;337:949-955. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/9395428 .

174. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative

radiotherapy in high-risk postmenopausal breast-cancer patients given

adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG

82c randomised trial. Lancet 1999;353:1641-1648. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/10335782

.

175. Ragaz J, Olivotto IA, Spinelli JJ, et al. Locoregional radiation

therapy in patients with high-risk breast cancer receiving adjuvant

chemotherapy: 20-year results of the British Columbia randomized trial.

J Natl Cancer Inst 2005;97:116-126. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/15657341

.

176. Recht A, Edge SB, Solin LJ, et al. Postmastectomy radiotherapy:

clinical practice guidelines of the American Society of Clinical Oncology.

J Clin Oncol 2001;19:1539-1569. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/11230499

.

177. Huang EH, Tucker SL, Strom EA, et al. Postmastectomy radiation

improves local-regional control and survival for selected patients with

locally advanced breast cancer treated with neoadjuvant chemotherapy

and mastectomy. J Clin Oncol 2004;22:4691-4699. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/15570071

.

178. McGuire SE, Gonzalez-Angulo AM, Huang EH, et al.

Postmastectomy radiation improves the outcome of patients with locally

advanced breast cancer who achieve a pathologic complete response

to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys

2007;68:1004-1009. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/17418973

.

179. Overgaard M, Nielsen HM, Overgaard J. Is the benefit of

postmastectomy irradiation limited to patients with four or more positive

nodes, as recommended in international consensus reports? A

subgroup analysis of the DBCG 82 b&c randomized trials. Radiother

Oncol 2007;82:247-253. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/17306393

.

180. Whelan TJ, Pignol JP, Levine MN, et al. Long-term results of

hypofractionated radiation therapy for breast cancer. N Engl J Med

2010;362:513-520. Available at:

http://www.ncbi.nlm.nih.gov/pubmed/20147717

.