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Relative frequency (%)

0

20

40

60

80

0

5

10

15

20

Tumour

Nordsmark et al. Acta Oncol 1994

a) Heterogeneity in hypoxia (%) amongst patients

Oxygen partial pressure (mmHg)

0

20

40

60

80

0

5

10

15

20

Normal tissue

Relative frequency (%)

Fraction pO

2

< 2.5 mmHg (%)

0 10 20 30 40 50 60 70 80 90 100

Relative frequency patients (%)

0

20

40

60

80

100

Dead (n=42)

Alive (n=24)

Oxygen partial pressure (mmHg)