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Summary: Radiotherapy 2

Pronounced differences in types

of radiation-induced 2

nd

cancers exist

between children, young adults and elderly patients treated with

radiotherapy

Types of 2

nd

cancers after radiotherapy are

different

from those induced

by low-dose total body irradiation,

e.g.

in the A-bomb survivors

Different biological mechanisms

can lead to 2

nd

cancers after

radiotherapy, depending on dose distribution and age of the irradiated

patient. Dose risk relationships, therefore, can be complex

Risk

of radiotherapy-induced 2

nd

cancers should

not

be estimated

using the effective dose method proposed by ICRP

for radiation protection purposes