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Summary: Radiotherapy 1

In radical radiotherapy, radiation exposure to non-involved organs and

tissues may cause 2

nd

cancers

several decades later

In adult cancer patients, the risk of radiation-induced 2

nd

cancers is

much smaller

than the risk of recurrent primary cancer

In adults, >90% of 2

nd

cancers after radiotherapy are due simply to

increased life expectancy

after cure of primary

Risk of radiation-induced 2

nd

cancers is much

greater in younger

cancer patients; these increased cancer rates may persist lifelong

Most radiation-induced 2

nd

cancers occur in the

high-dose volume

but also appear in the low dose (<2 Gy) volume