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pO

2

< 10mmHg

pO

2

> 10mmHg

Radiotherapy

Time (months)

1.0

0 10 20 30 40 50 60 70 80

Log-rank p = 0.01

0.8

0.6

0.4

0.2

0

Höckel M. et al. Cancer Res 56, 4509-4515 (1996)

Treatment resistance - Radiotherapy