1170-1171 / 2063
ARCON for cT2-4 larynx carcinoma
48
Accelerated Radiotherapy
Accelerated Radiotherapy
+
carbogen and nicotinamide
Fractionation schedule:
primary
metastatic nodes
Acc. RT
68 Gy
68 Gy
ARCON
64 Gy*
68 Gy
*Aim: improve tumor control with equal toxicity between arms!
Randomization
Janssens et al., J Clin Oncol 2012