1442-1443 / 2063
Tumors showing high
EGFR expression
Example 1: Target driven lethality - EGFR
• NSCLC
40-80%
• Prostate
40-80%
• Gastric
33-74%
• Breast
14-91%
• Colorectal
25-77%
• Pancreatic
30-50%
• Ovarian
35-70%
• Bladder
31-48%
• Renal cell
50-90%
• H&N
80-100%
• Glioma
40-63%
• Esophageal
43-89%
High expression generally
associated with
•
Invasion
•
Metastasis
•
Late-stage disease
•
Chemo-/Radiotherapy
resistance
•
Poor outcome