1528-1529 / 2063
EGFR inhibition + RCT in HNSCC
•
Benefit with
chemotherapy
? RTOG0522 trial
•
Randomized Phase III, stage III and IV HNSCC
•
Concurrent accelerated radiation + cisplatin (arm A; n =
447) vs concurrent accelerated radiation + cisplatin +
cetuximab (arm B; n = 444)
•
Adding cetuximab to radiation-cisplatin did not improve
outcome; leads to more acute grade 3-4 toxicity
Ang KK, JCO 2014;32:2940