1612-1613 / 2063
Top-up dose [Gy]
0 2 4 6 8 10 12 14 16 18
0
10
20
30
40
50
60
70
80
90
100
Amifostine
week 1
co.
s.c.
i.v.
Frequency of responders [%]
p=0.0014
p=0.0099
0 2 4 6 8 10 12 14 16 18
Amifostine
week 2
Top-up dose [Gy]
10x3 Gy / 2 weeks
Fleischer and Dörr, Strahlenther. Onkol. 182, 2006, 567-575
oral mucosa,
mouse
ulcer induction
Radical scavenging/detoxification
Targeting Free Radical Production