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Definitions
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Tumor volume doubling time (VDT): time required for tumor to
double its volume
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Growth fraction (GF): cells in the compartment of actively
dividing cells
•
Cell-cycle time (Tc): time required to complete the cell cycle
•
Ts: duration of S-phase
•
Potential doubling time (Tpot): cell doubling time without any
cell loss (Tpot = Tc/GF)
•
Cell loss factor (CLF): tumor cell loss during growth
(CLF = 1 – Tpot/VDT)
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