1862-1863 / 2063
Summary growth delay assay
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Dependent on reliable volume measurement (difficult!)
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with ultrasound imaging or bioluminescence more reliable
than manual caliper
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Only suitable for few logs of tumor cells (selection)
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Reflects growth rate of clonogenic and non-clonogenic
cells
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Dependent on growth rate of tumor
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comparison of different tumors difficult
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drugs may change growth rate (overestimation of efficacy)
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radiation damage of vessels changes growth rate (tumor bed
effect; overestimation of efficacy)