Microsoft Word - RadBio_Programme_ParisSept2017

Mitotic Catastrophe

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Mitotic catastrophe takes place at long times after irradiation

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Depends on proliferation rate

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Influenced by DNA repair capacity

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Cell death may occur at different times following mitotic catastrophe

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Nuclear fragmentation

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Apoptosis, necrosis, senescence, autophagy

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Cells may attempt several divisions

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Multiple failed divisions

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Cell fusions

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Giant cell formation, multiple micronuclei

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Genome becomes so unstable as to no longer support normal cell

function