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ESTRO
2017
Healthy
tissues
Tumor
Reduction of radiosensitivity differences
:
Potential therapeutic advantage
when the tumor is radioresistant
in comparison with healthy tissues
Potential therapeutic benefit due to the
reduction
of an
unfavourable
differential effect
Dose
(low LET)
Dose
(
high LET)
Surviving Fractions (%)
Surviving Fractions (%)
HT
Tumor
ESTRO
2017
Healthy
tissues
Tumor
Reduction of radiosensitivity differences
:
contra-indication
when the healthy tissues are radioresistant
In comparison with the tumor
Contra-indication due to the
reduction
of
a
favorable
differentiel effect
Surviving Fractions (%)
Surviving Fractions (%)
Dose
(low LET)
Dose
(
high LET)
T
Healthy tissues
ESTRO
2017
Mohamad et al, Cancers, 2017
Ion beam therapy: clusters of DNA damages