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14

ESTRO

2017

REGION

LESION

Brain and spinal cord

Isolated brain metastases

Selected brain tumor recurrences

Pituitary adenomas

Arteriovenous malformations (AVMs)

Base of skull

Meningiomas

Acoustic neuromas

Chordomas and chondrosarcomas

Eye

Uveal melanomas

Macular degeneration

Head and neck

Nasopharynx (primary and recurrent) tumors

Oropharynx (locally advanced) tumors

Paranasal sinus tumors

Chest and abdomen

Medically inoperable non-small-cell lung cancer

Chordomas and chondrosarcomas

Hepatic tumors

Retroperitoneal tumors

Paraspinal tumors

Pelvis

Prostate tumors

Chordomas and chondrosarcomas

Pediatric lesions

Brain and spinal cord tumors

Orbital and ocular tumors

Sarcomas of the base of skull and spine

Abdominal and pelvic tumors

PROTON THERAPY INDICATIONS

Suit, 2010

ESTRO

2017

Comparison between CRT and SBRT for stage I NSCLC

Grutterset al., 2009

Retrospective single arm studies: 1994-2008

30 studies included (2611 patients, published data)

Treatment

#pts

EQD

2,T

(Gy)

#Fractions

CRT

1326

42-63

20-43

SBRT

895

33-176

3-10

Protons

180

63-111

2-6

ESTRO

2017

Randomized phase III trials with proton therapy published as

of August 2017

Shipley et al., 1995