212-213 / 2063
Conclusions
•
Most cell death is controlled or programmed in some way.
–
Major pathways include apoptosis, senescence, autophagy and
necrosis
•
Measuring one form of cell death (eg Apoptosis) will not
necessarily correlate with how many cells die
–
Cell may die by other mechanisms
•
The form of cell death may influence the rate at which cells
die
–
Affect tumor regression
•
Genetic changes may dramatically alter how cells die
without changing if they will die