794 / 2063
ESTRO
2017
Five versus six fractions of radiotherapy per week
for squamous-cell carcinoma of the head and neck
(IAEA-ACC study): a randomized, multicentre trial
Overgaard et al. Lancet Oncol, 2010
IIIIII IIIIII IIIIII IIIIII IIIIII IIIIII
66-70 Gy/ 2.0 Gy/ 5.5-6.0 w
IIIII IIIII IIIII IIIII IIIII IIIII IIII
66-70 Gy/ 2.0 Gy/ 6.5-7.0 w
ESTRO
2017
EORTC - Head & Neck (22851)
SCC, T2-4 N0-3 M0, WHO 0-2 (n=500)
IIIII I IIIII IIII
IIIII I IIIII IIII
IIIII I IIIII IIII
72 Gy/ 3 x 1.6 Gy/ ti 4 h/ Pause 12-14d/ 5w (n=247)
Horiot et al.,
Radiother. Oncol.
44: 111-121, 1997
Accelerated RT:
• Tumor control increased
• Survival identical
• Very severe early NT reactions
IIIII IIIII IIIII IIIII IIIII IIIII IIIII
70 Gy/ 1.8-2.0 Gy/ 7 w (n=253)