802 / 2063
ESTRO
2017
0
20
40
60
80
40
50
60
70
80
90
100
HYPOFRACTIONATION I HYPERFRACTIONATION
1.0 Gy
d/Fr =
1.6 Gy
4 - 5 Gy
1.2 Gy
2 Gy
Tumor with
a/b
= 10 Gy
Late complications
a/b
= 3 Gy
Current data with prostate
tumors at
a/b
= 1.5 Gy
Total Iso-effect Dose (Gy)
Number of dose fractions
Radiobiological and clinical issues in IMRT for prostate C
Courtesy of K. Haustermans
ESTRO
2017
Conformal irradiation for prostate tumors
3D-
CRT
IMRT
Dearlaney, 1999
≥ grade 2 proctitis: 15% >< 5% (p= 0.01)