930-931 / 2063
ESTRO BCR Course / Volume effect in RT – W. Dörr
parallel organisation
Concept of Functional Sub-Units (FSUs)
functional damage, if a critical number
of FSU’s is inactivated
(threshold volume)
risk of complication ~ total dose
distribution rather than on “hot spots”
Inactivation of one subunit can lead
to loss of organ function (binary
response)
risk of complication strongly
influenced by “hot spots”
serial organisation
lung
liver
kidney
spinal
cord
esopha-
gus
intestine