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Increased toxicity

No increased toxicity

Timmerman 2008

3

x 20 / 22 Gy

Joyner 2006

3

x 12 Gy

6

x 6 Gy

Song 2009

3-4

x 10-20 Gy

Senan 2007

8

x 7.5 Gy

Chang 2008

4

x 12.5 Gy

Guckenberger 2009

8

x 6 Gy

Milano 2009

10

x 3-5 Gy

Oshiro 2010

5

x 10 Gy

Is this „

EXCESSIVE TOXCITY

“ really unexpected

after RT with

EXCESSIVE DOSES

?

Risk adapted fractionation

M Guckenberger - SBRT stage I NSCLC - HICARE 2015

21