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De-intensification of elective neck irradiation
• Decrease in target volume:
– Disphagia-sparing IMRT:
Feng et al.
JCO
2010;28:2731-8.
• Decrease in dose:
– Dose de-escalation:
Phase II RCT NCT01812486;
Phase III RTC RTOG 1016.
• Decrease in target volume & dose:
– Omitting elective neck at lower risk of occult metastases from irradiation to
NID2Gy 40 Gy:
Phase II RCT NCT01287390.
– Irradiation of sentinel lymph nodes in T1-2N0 cancer of oral cavity?
Can we improve the results of elective neck irradiation?