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Optic nerve tolerance & risk
Emami 1991 – (blindness within 5 years)
Probably too conservative
5% risk 50 Gy 50% risk 65 Gy
Mayo 2010 – for 1.8 – 2.0 Gy/#
50 Gy = “near zero” incidence
3 – 7% risk 55 – 60 Gy (? 5% for 57.5 Gy)
(Tolerance
might
be lower with co-morbidity)
Emami B et al IJROBP 1991; 21: 109-122
Mayo C et al IJROBP 2010; 76(3 Suppl): S28–S35 (QUANTEC)