597 / 1726
GUSTAVE ROUSSY
THÈME DU DIAPORAMA
Adverse effects
Arm A - More Grade 3-4 toxicities (p<0.001)
Haematologic Toxicity
Grade 3-4 ; 71.9% vs 23.9 %
Non haematologic toxicities
Vomiting & diarrhea more in arm A (p=0.002)
Hospitalization during treatment
Arm A -30 pts & Arm B -11 pts (p=0.02)
3 deaths in arm A – 2 due to sepsis and bowel perforation & 1 due to
acute encephalopathy
Late toxicities slightly higher in Arm A
–
Grade 4 GI : 2.3 % Vs 0%