AOAC SPDS Meeting Book March 19 2015

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Speciociliatine
Background (Diastereoisomers of Mitragynine)
Speciogynine
(S)
(S)
(S)
(S)
(S)
(R)
 Kratom – should be slotted appropriately
 comfrey
 ephedra
Regulatory Guidance
 rauwolfia
 red yeast rice
 butterbur
 Kratom could fit under 201(ff) as an herb or other botanical
(alkaloids with opioid activity are the issue)
 Kratom (mitragynine or 7‐hydroxymitragynine)
= adulterated based on 402(f)(1)(B)
 Kratom (mitragynine and 7‐hydroxymitragynine removed)
= allowable? (all other alkaloids left ‐ cause relaxation)
 At what level would they be acceptable?
 Zero tolerance? Agency has to make that case