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9/13/2016
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Stakeholder Panel on Strategic
Food Analytical Methods:
Background and Fitness for
Purpose for
Proanthocyanidins in
Cranberry Products
Brian Schaneberg
Dallas, TX
September 18, 2016
Background on the Analyte
▪
Cranberry juice has been used traditionally for the treatment and prevention of
urinary tract infections
▪
Effectiveness first demonstrated by Avorn, et. al. in a randomized, double-blind,
placebo-controlled study in 1994
▪
Sobota first proposed a bacterial (
E. Coli
) anti-adhesion (uroepithelial cell)
mechanism for cranberry in 1984
▪
Howell, et. al. used an anti-adhesion bioassay directed fractionation of cranberry
juice and identified A-Type proanthocyanidins as the active components in 1998
▪
Feliciano, et. al. have also shown A-type PACs inhibited gut colonization of
uropathogenic
E. coli
in 2013