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4
General Analytical Needs
Recognize two basic analytical needs:
1.
Quantitative QC method to support product manufacture
a)
Quick
b)
Easy
2.
Qualitative method to verify authenticity
Challenges
▪
Recognize four primary challenges in the analysis of cranberry proanthocyanidins
1.
Analyte heterogeneity and complexity
a)
Not a single compound
b)
Wide range of DP and Isomers
c)
Differentiating structural characteristic (A-type versus B-Type)
2.
Range of solubility impacts sample preparation and analysis
3.
Lack of standards
a)
Results differences between methods
4.
Achieving methodology consensus