59 / 228
21
Hazelnutsandpeanutarenotdefinedinsenseoftheirvarietywhilemilkandeggarenotdefined
insenseoftheirorigin
Amethoddevelopershouldvalidatethedifferencesbetweendifferent
varietiesofhazelnutsandpeanutsinsenseoftraceabilityand
measurementuncertainty.
Amethoddevelopershouldvalidatedifferentspeciesthatdelivermilk
(cow,goat,sheeoetc.);sameforegg.MaybeaninͲsilicoanalysisof
peptidesequencesissufficient.
SpeciesnameswereaddedtotheSMPR. Theworkinggroup
groupdidnotagreetorequireingdifferentvarieties.
22
Theterm"allergen"isnotdefined
TheSMPRshouldcontainaclarifyingchapterorclausethatexplains
thattheterm“allergen”isusedinananalyticalandnotimmunological
way.“Allergen”couldalsomeanaspecificproteinfromhazelnutthat
differsbetweenregionsandvarieties.
Nochangerecomended.
Althoughtheterm"allergen"itselfis
notdefined,theidentificationoffoodallergenstypesinthe
SMPRprovidesalloftheneededinformationformethod
developers. Nodefinitionwerefoundthatweren'tcircular.i.e.,
anallergenisamoleculecausesanallergicreaction.
23
AgeneralproblemofthisSMPRistraceabilityofresults.Indetail,anLCͲMS/MSuserprepared
peptidesolutionsonaweightbyweightbasisandusesreferencematerialsalsoonaweightby
weightbasis.Arethesereferencematerialsofahigherorderinthecalibrationhierarchyorarethe
peptidesofhigherlevel?Furthermore,howshouldwereͲcalculatetothe“analyte”whichisfor
example“milk”.ThereisnoconversionfactortoreͲcalculatefrom“weightwholemilkpowder
fromNIST”to“milk”.Evenmoreproblematicistherecalculationfrom“peakareaofaspecificmilk
peptide”to“milk”.
Ataminimum,eachvalidationreportshouldcontainachapterthat
clearlydescribeshowthevalidationmanagersolvedthisfundamental
problemforeachallergenordescribesthelimitationsofquantitative
results.
WorkingGroupagreedthatallresultstobe"reportedasppmof
thetargetallergeninfoodcommodity".
24
Ihavedevelopedasignsystemforthe14allergenswhich,accordingtotheEuropeanUnion,must
beindicatedinfoodpackagings.Ithasbeingtheworkof7monthsformyfinalgradeinGraphic
Design.
Implementyourstandardregulationbyapplyingthesignsystemfor
theallergens(eggs,milk,nuts,peanuts,celery,sesame,mustard,
sulphites,fish,crustaceans,mollusks,gluten,lupinandsoy).Itwould
helptotheinterpretationoftheingredientsindependentlyfromthe
countrywherepeopleliveorthelanguagethattheyspeak.Thankyou
Nochange.
Irrelevant
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