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• CROSS - 2015 (Trimodality)

T1N1+T2-3N0-1M0

Junction= 24%

366 pts

Adeno 75%

Preoperative

Chemoradiation

Planned Esophagectomy

Treatemet related mortality

chemoradiotherapy + surgery:

4%

Van Hagen

et al

; N Engl J Med 2012

Oppedijk

et al;

JCO 2014

Shapiro

et al

; Lancet Oncol 2015

The Netherlands

surgery alone:

4%

p=ns