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State of art of radiation therapy in Esophageal Cancer
Preoperative
Chemoradiation
Planned Esophagectomy
•
Walsh et al – 1996 (Trimodality)
Phase III Trial Chir
±
Preop RTCT
•
CROSS - 2015 (Trimodality)
Phase III Trial Chir
±
Preop RTCT
•
POET - 2009 (Trimodality)
Phase III Trial Chir + Preop CT
±
RT
•
Urba et al – 2001 (Trimodality)
Phase III Trial Chir
±
Preop RTCT
•
Burmeister et al – 2005 (Trimodality)
Phase III Trial Chir
±
Preop RTCT
•
Tepper et al – 2008 (Trimodality)
Phase III Trial Chir
±
Preop RTCT
•
FFCD 9901 - 2014 (Trimodality)
Phase III Trial Chir
±
Preop RTCT
Chemoradiation
or
Selective Esophagectomy
• FFCD 9102 - 2015
Phase III Trial RTCT in > PR RTCT vs Selective Chir
• ESSEN Trial - 2005
Phase II Trial RTCT
±
Selective Chir
Definitive
Chemoradiation
Salvage Esophagectomy
•
RTOG 85-01 - 1999
Phase III Trial RT vs RTCT
•
INT 0123 - 2002
Phase III Trial RTCT (50Gy) vs RTCT (65Gy)