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PTV in practice?

… Use

coverage probabilities

to derive margins ...

... This idea is limited to effects expressed in terms of physical

dose, biological response parameters are not included ...

Stroom

et al.

:

99% of target volume receives 95% of the prescribed

dose or more

Van Herk

et al.

:

90% of patients in the population receives a

minimum cumulative CTV dose of at least 95 % of the prescribed

dose

.

… Not all patients will be treated to 100% of the prescription

dose in all fractions!!!

The PTV 2017 - D. Verellen