829 / 1084
D2 Surgery
1x 5-FU
R
n
=275
n
=281
Observation
Chemoradiotherapy
45 Gy/25 fx + 5-FU/ LV
2x 5-FU
R
Surgery < 6 wks
n
=240
3x ECF
n
=237
Surgery 3-6 wks
3x ECF 6-12 weeks
n
=253
n
=250
n
=219
n
=137
n
=104
SWOG-Intergroup 0116 Trial
MAGIC Trial
Evidence-based (neo-)adjuvant strategies (1)
Cunningham et al. NEJM 2006
Macdonald et al. NEJM 2001; Smalley et al. JCO 2012